J Med Life Sci > Volume 11(2); 2014 > Article
Journal of Medicine and Life Science 2014;11(2):118-121.
DOI: https://doi.org/10.22730/jmls.2014.11.2.118    Published online December 18, 2018.
결핵약제에 의해 발생한 DRESS syndrome과 그 이후에 발생한 multiple drug hypersensitivity
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DRESS syndrome due to Anti-Tuberculous Drug
So Yeon Yoo, Jaechun Lee, Jong Hoo Lee, Mi Ok Kim
DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life threatening syndrome caused by exposure to certain medications. That may cause skin rash, fever, inflammation of internal organs, lymphadenopathy, and characteristic hematologic abdnormalities such ad eosinophilia, thrombocytopenia, and typical atypical lymphocytosis. The interval between the starting of drug therapy and the onset of cutaneous reactions may be at least one month. Aromatic anticonvulsants (phenytoin, phenobarbital, carbamazepine) and sulfonamides are the most common causes of DRESS. There has been only a few case reports of DRESS syndrome induced by anti-tuberculous medication, Ethambutol, Rifampin, Isoniazid, Pyrazinamide. We report a case of Ethambutol induced DRESS syndrome and multiple drug hypersensitivity to other antituberculosis drugs that were used at after DRESS syndrome developed.
Key Words: Drug Hypersenitivity Syndrome, ethambutol
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