| 만성 콩팥병 환자에서 약물 용량의 결정 |
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김현우 |
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제주대학교 의과대학 내과학교실 |
| Drug dosing in patients with chronic kidney disease |
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Hyun Woo Kim |
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Department of Internal Medicine, Jejuju National University College of Medicine, Jeju, Korea |
Correspondence:
Hyun Woo Kim, Email: andrewmanson@jejunuh.co.kr
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| Abstract |
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The prevalence of chronic kidney disease (CKD), is increasing in korea and patients with CKD usually have other comorbidities such as diabetes mellitus, hypertension, coronary artery disease and infection. Thus, more drugs had been prescribed ln CKD patients than in patients with normal kidney function, Patients with renal impairment often show pharmacokinetic parameters (eg, drug absorption, distribution, protein binding, biotransformation, renal excretion) that are different from those of patients with normal kidney function, Patients can also show an altered pharmacodynamic response to a given drug due to the physiological and biochemical changes associated with progressive renal insufficiency, Hence, appropriate drug selection and dosing for patients with CKD is important to avoid unwanted drug effects and ensure optimal outcomes. Dosing errors are some of the most important drug-related problems in patients with CKD and most of dosing errors occur when physicians order drugs due to lack of knowledge about the drug or lack of information about the patient. This article reviews the importance to dosage adjustment in patients with CKD and methods have been suggested to assist physicians monitoring and adjusting drug therapy in CKD patients. |
| Key Words:
Chronic kidney disease, Renat dosage adjustment |
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