| 패턴인지 수용체와 병원체의 인지 |
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고영상 |
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제주대학교 의학전문대학원 미생물학교실 |
| Pattern-recognition receptors and recognition of pathogens |
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Young-Sang Koh |
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Department of Microbiotogy，Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Young-Sang Koh, Email: ySkoh7@jejunu.ac.k
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| Abstract |
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The mammalian host has evolved innate immune strategies to detect and respond to rapidly to diverse group of microorganisms. Microbial recognition is achieved by pattern-recognition receptors (PRRs) such as toll-like receptors (TLRs) and Nod-like receptor (NLRs). PRRs detect pathogen-associated molecular patterns (PAMPs) and activate downstream signalling pathways. NLRs have been proposed thal these cytosolic proteins regulate the cysteine protease caspase-1 within a multiprotein complex known as the inflammasome. Activation of caspase-1 leads to the cleavage and activation of proinflammatory cytokines such as interleukin-1β (lL-1β) and IL-18. |
| Key Words:
Toll-like receptor; Nod-like receptor; Proinflammatory cytokine; Inflammasome |
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