| Streptozotocin을 이용한 제1형 당뇨 유발 흰쥐에서 KIOM-79의 효과 |
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| Effects of KIOM-79 on streptozotocin-induced insulin-dependent diabetes in Sprague-Dawley rats |
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In-youb Chang |
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Chosun University |
Correspondence:
In-youb Chang, Email: iyjang@chosun.ac.kr
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| Abstract |
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We investigated the effect of KIOM-79, 80 % ethanolic extract of herbal prescription isolated from Magnolia officinalis, Pueraria lobate, Glycyrrhiza uralensis, and Euphorbia pekinensis, on streptozotocin-induced diabetes in Sprague-Dawley rats. The rats were treated orally with KIOM-79 (500 mg/kg) once a day 1) 3 days prior to streptozotocin (60 mg/kg, intraperitoneal) injection or 2) for 9 weeks to examine acute and chronic effects on hyperglycemia and biochemical variables. As a result, we found that KIOM-79 had little effects on hyperglycemic changes in acute model. Sexual comparison, however, showed reduced hyperglycemia in female rats, especially 24 hours after streptozotocin injection with or without KIOM-79 pretreatment. In chronic model, we found that streptozotocin-induced hyperglycemia was well established, but KIOM-79 treatment showed no statistically significant effects on all variables. Thus, based on our findings KIOM-79 might have little effects on streptozotocin-induced diabetes (i.e. insulin-dependent diabetes) although it had hypoglycemic and anti-diabetic effects on non-insulin-dependent diabetes models. |
| Key Words:
KIOM-79, Diabetes, Streptozotocin |
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