| 미세신경교세포 조절을 통한 제주조릿대 추출물의 신경세포 보호작용 |
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| Neuroprotective effects of Sasa quelpaertensis leaf extract against microglia-mediated neurotoxicity |
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Ji Hyung Lee, Jee-Yun Park, Yan Ji Cui, Se-Jae Kim, Joo Min Park, Sung-Cherl Jung, Su-Yong Eun |
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| Abstract |
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Sasa quelpaertensis leaf extract (SQE) has shown various biological effects in several tissues. However, the pharmacological
effect of SQE has never been investigated yet in the central nervous system. Therefore, we investigated whether the hot water
extract from Sasa quelpaertensis Nakai suppresses lipopolysaccharide (LPS, 100 ng/ml)-induced microglial activation. The
results demonstrated that SQE significantly reduced NO production in LPS-stimulated BV-2 microglial cells. In addition, SQE
showed free radical scavenging activity in DPPH assay. Taken together, these results suggest that SQE may have a therapeutic
potential against neuroinflammation and neurodegeneration through suppression of excess microglial activation-mediated
neuronal cell death. |
| Key Words:
Neuroinflammation, Microglial activation, Neuronal death, Reactive oxygen species, Nitric oxide, Sasa
quelpaertensis |
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