Effect of rutin on the accumulation of lipid in H4ⅡE hepatoma cells

Lee, Ho-Won; Park, Deok-Bae

doi:2014.11.2.106

J Med Life Sci > Volume 11(2); 2014 > Article

Original Article

Journal of Medicine and Life Science 2014;11(2):106-109.
DOI: https://doi.org/10.22730/jmls.2014.11.2.106 Published online December 18, 2018.

Rutin이 H4IIE 간세포에서 지질축적에 미치는 영향

Effect of rutin on the accumulation of lipid in H4ⅡE hepatoma cells

Ho-Won Lee, Deok-Bae Park

Abstract

Rutin is a flavonoid compound present within various plants. Previous studies have suggested that rutin has a potential antidiabetic and a anti-cancer activity in a few experimental models. However, it is uncertain that rutin can affect hepatic lipid accumulation, which is a pathophysiological marker of steatohepatitis (fatty liver) in metabolic syndrome. The present study investigated the effect of rutin on the intracellular accumulation of lipid induced by palmitic acid in H4IIE rat hepatoma cells. Rutin significantly suppressed palmitic acid-induced lipid accumulation whereas other flavonoid compound (hesperidin) did not. Protein content of the key enzyme in the biosynthesis of triglyceride, FAS, was decreased by rutin. The number of intracellular lipid droplets was also suppressed by rutin. Taken together, rutin has a strong anti-lipogenic activity, indicating the pharmacological potential to treat one of metabolic syndrome.

Key Words: rutin, lipid accumulation, H4IIE hepatoma cells0