J Med Life Sci > Volume 11(1); 2014 > Article
Journal of Medicine and Life Science 2014;11(1):82-86.
DOI: https://doi.org/10.22730/jmls.2014.11.1.82    Published online December 18, 2018.
Magnetic Resonance Imaging Findings in the Brains of Patients with CADASIL.
Jung Seok Lee, Chul-hoo Kang, Jung-Hwan Oh, Sook Keun Song, Jay Chol Choi, Sa-Yoon Kang, Ji-Hoon Kang, Bong-hee Jeon, Joon Hyuk Park
Correspondence:  Jung Seok Lee,
Abstract
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited microangiopathy caused by mutations in the Notch3 gene. Typical findings from magnetic resonance imaging (MRI) include multiple subcortical lacunes, extensive white matter change and multiple cerebral microbleeds (CMBs). Whereas MRI findings are well described in Caucasian patients with CADASIL. There is a paucity of data on Asian patients. We aim to characterized imaging findings in Asian patients with CADASIL. The study population comprised 73 patients who underwent brain MRI between March 2012 and May 2013. T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery (FLAIR) images were analyzed by visual inspection. Clinical information at time of imaging was available for all patients. The mean age of patients (44 men, 29 women) was 63.2±11.8 (SD). In patients with CADASIL, lacunes (76.7%, 56 of 73), CMBs (74%, 54 of 73), and area of white mater hyperintensities (98.6%, 72 of 73) were observed. Lacunes, CMBs, and WMHs were located predominantly in the cortical-subcortical lesion (57.5%, 54.8%, and 98.6%, respectively). These findings suggest that cortical-subcortical area is the most frequently injured area of brain in CADASIL. Further studies are needed to validate our findings.
Key Words: Cerebral Autosomal-dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), Lacunes, Cerebral Microbleeds (CMBs), White Matter Change, Cortical-subcortical Area.
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