| Recurrent angiosarcoma of spleen presented with pancytopenia due to metastasis to bone marrow |
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Young Ree Kim1, Woo Kun Kim2, Soyoung Hyun2, Young-Hee Maeng3 |
1Department of Laboratory Medicine, School of Medicine, Jeju National University, Jeju Korea
2Department of Internal Medicine, School of Medicine, Jeju National University, Jeju Korea
3Department of Pathology, School of Medicine, Jeju National University, Jeju Korea |
Correspondence:
Young Ree Kim, Email: namu8790@jejunu.ac.kr
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| Abstract |
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The patient was a 72 year old male who was referred to Jeju National University Hospital for pancytopenia. Three years prior to this, he visited another hospital for abdominal pain, splenomegaly and thrombocytopenia. His bone marrow was normal at that time. He had an history of hypertension, diabetes, and Parkinson's disease. Laboratory findings showed pancytopenia with leuko-erythroblastic feature. Chest X-ray did not showed a remarkable findings but chest CT scan showed small nodules on bilateral lower lung fields. increased interstitial markings and minimal bilateral pleural effusion. Bone marrow aspiration and biopsy showed tumor infiltration. positively stained for CD34 and negative for common leukocyte antigen. cytokeratin, actin, HMB45, NSE and PSA. Based on the described findings， the diagnosis of angiosarcoma involving the bone marrow was made. Despite treatment with imatinib. he was expired with pulmonary hemorrhage after 3 years from diagnosis. |
| Key Words:
angiosarcoma, bone marrow，melastasis |
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