J Med Life Sci > Volume 6(5); 2009 > Article
Journal of Medicine and Life Science 2009;6(5):368-372.
DOI: https://doi.org/10.22730/jmls.2009.6.5.368    Published online May 27, 2009.
Protective effect of dieckol on γ-ray radiation-induced V79-4 lung fibroblast cell damage involved in modulation of reactive oxygen species
Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyun
Department of Biochemistry, Jeju National University School of Medicine, Jeju, Korea
Correspondence:  Jin Won Hyun, Email: jinwonh@jejunu.ac.kr
Abstract
lonizing radiation can induce oxidative stress through generation of reactive oxygen species (ROS) resulting in cell damage and cell death. We have investigated the radioprotective effect of dieckol, which was isolated from Ecklonia cava, against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Dieckol was found to reduce the intracellular ROS generated by γ-ray radiation. Moreover, dieckol also protected the cell viability damaged by the radiation through inhibition of apoptosis. Irradiated cells with dieckol treatment reduced. the expression of phospho histone H2A.X (a marker for DNA strand breakage) and the activation of caspase 9, which were induced by radiation. These results suggest that dieckol protected γ-ray radiation induced apoptosis of V79-4 lung fibroblast cells by inhibiting ROS generation.
Key Words: Dieckol; Reactive oxygen species; Cell damage; Apoptosis


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