| Galangin protects hydrogen peroxide induced oxidative stress via the scavenging of reactive oxygen species |
|
Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyun |
|
Department of Biochemistry, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Jin Won Hyun, Email: jinwonh@jejunu.ac.kr
|
|
|
| Abstract |
|
Flavonoids are a class of secondary metabolites abundantly found in fruits and vegetables. In addition, flavonoids have been reported as potent antioxidants with beneficial effects against oxidative stress related diseases such as cancer, aging, and diabetes. Galangin (3, 5, 7-trihydroxyfravone)，a member of the flavonol class of flavonoid, is present in high concentrations in medicinal plants (e.g. Alpinia officinarum) and propolis, a natural beehive product. The present study was carried out to investigate the protective effects of galanin against hydrogen peroxide (H202) induced oxidative stress. Galanginwas found to quench the 1, 1-diphenyl-2-picrylhydrazyl (DPPH)radical and intracellular reactive oxygen species generated by H202 treatment in cells, which is detected by a spectrofluorometer after staining of 2’,7' -dichlorodihydrofluorescein diacetate (DCF-DA). These results suggest that galangin protected V79-4 lung fibroblast cells against H202-induced oxidative stress via the scavenging of reactive oxygen species (ROS). |
| Key Words:
Galangin, Reactive oxygen species |
|
PDF Links
Full text via DOI
Download Citation
