| Comparison of genetic and derived amino acid changes in full-Iength hepatitis B virus genome between the patients with self-Iimited acute hepatitis B and those with acute exacerbation (AE) in chronic hepatitis B (CHB) during HBeAg seroconversion. |
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Xiu-Ji Cui, Yoo-Kyung Cho, Hyun Joo Song, Eun Kwang Choi, Heung Up Kim, Byung-Cheol Song |
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Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Yoo-Kyung Cho, Email: choyk1120@hanmail.net
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| Abstract |
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The aim of study was to compare the genetic differences in full-length HBV DNA between the patients with acute hepatitis B (AHB) and those with acute exacerbation (AE) in chronic hepatitis B (CHB) during HBeAg seroconversion. The sequence was determined from serial sera of AHB (n=3) and CHB (n=3) at presentation and after HBeAg seroconversion. AII patients have been infected by subgenotype C2 of HBV. There was no marked genetic diversity in full-Iength genome of HBV between AHB and CHB during AE (CHB vs. AHB (%): 1.33 ± O.4g vs. 1.03 ± 0.25) and after HBeAg seroconversion (CHB vs. AHB (%): 1.40 ± 0.61 vs. 1.35 ± 0.35). However, ln C and Sgene, the genetic diversity was higher in patients with CHB than in those with AHB at AE (CHB vs. AHB (%): C gene, 1.23 ± 0.23 vs. 0.40 ± 0.17; S gene, 1.03 ± 0.55 vs. 0.57 ± 0.38), but il didn't show remarkable differences after H8eAg seroconversion (CH8 vs. AH8 (%): C gene, 1.23 ± 0.31 vs. 1.20 ± 0.71: S gene, 0.97 ± 0.61 vs. 0.75 ± 0.35). Interestingly, the substitutions in these genes were likely to occur on putative HLA class l/ll restricted epitopes, and the changes of gene in core and surface epitope-related codon were higher in CH8 Ihan AH8. In AH8, genetic change of C gene was higher after HBeAg seroconversion than in acute status (HBeAg H vs. acute status (%):C gene. 1.20 ± 0.71 VS. 0.40 ± 0.17). In contrast，there were no remarkable differences in CHB before or after H8eAg seroconversion. The different pattern of genetic variation that related to immune escape. between AHB and CHB might be associated with the different clinical consequences after HBeAg seroconversion. |
| Key Words:
Hepatitis B virus; Acute hepatitis B; Chronic hepatitis B; Acute exacerbation; HBeAg seroconversion |
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