J Med Life Sci > Volume 7(2); 2010 > Article
Journal of Medicine and Life Science 2010;7(2):18-21.
DOI: https://doi.org/10.22730/jmls.2010.7.2.18    Published online December 31, 2010.
제주지역 알레르기 환자의 Toll-like receptor 4 (TLR 4) 유전자의 다형성
이수현, 최현, 이혜숙, 홍주연, 박지연, 김수영, 홍성철, 이근화
제주대학교 의학전문대학원 환경보건센터
Toll-like receptor 4 (TLR 4) polymorphisms in allergic diseases patients in Jeju
Su-Hyun Lee, Hyun Choi, Hye-Sook Lee, Ju-yeon Hong, ji-yeon Park, Su-Young Kim, Seong-Chul Hong, Keun-Hwa Lee
The Environmental Health Center Jeju National University School of Medicine, Jeju, Korea
Correspondence:  Keun-Hwa Lee, Email: yomust7@jejunu.ac.kr
Abstract
A study was conducted to the Toll-like receptor 4 (TLR 4) polymorphisms in allergic diseases patients in Jeju. This study based on "a TLR 4 polymorphism is associated with asthma and reduced Iipopolysaccharide induced interleukin-12(p70) responses in Swedish children" (J Allergy Clin Immunol. 2004 Sep:114(3):561-7.) With allergic subject 40 people registered in the Environmental Health Center Jeju National University School of Medicine (atopy dermatitis and allergie rhinitis, asthma) and 24 people control group DNA used gene amplification and base sequence analyzed. The allergic subject and control group all TLR 4 (Asp299Gly) polymorphism were not visible.
Key Words: Allergy; Toll-like receptor 4; Polymorphisms


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