| 전신 고열자극이 랫트 자가면역성 뇌척수염에 미치는 영향 |
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안미정 |
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제주대학교 의학전문대학원해부학교실 |
| Whole-body hyperthermia attenuates rat experimental autoimmune encephalomyelitis |
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Meejung Ahn |
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Department of Anatomy, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Meejung Ahn, Email: healthY@jejunu.ac.kr
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| Abstract |
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Hyperthermia has been known to induce transient expression of 27 kDa heat shock protein (HSP27) in several types of cells in the central nervous system Little is known about the effects of whole-body hyperthermia in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) in the rat. The aim of this study was to examine whether whole body hyperthermia affect the clinical symptoms of EAE in rats. EAE was induced in Lewis rats that were immunized with guinea pig myelin basic protein (MBP)and complete Freund’s adjuvant. At 7 days after immunization, the immunized rats were divided into three groups including placed into a 42t incubator for 10 minutes, for 20 minutes and room temperature. The onset, severity, and duration of EAE paralysis in the whole body hyperthermia treated groups in the day 7 Pl-treated rats were significantly delayed, suppressed, and reduced, respectively, compared with those of the EAE control group. Moreover, the clinical amelioration coincided with decreased infiltration of inflammatory cells in the EAE-affected spinal cord. Collectively, whole body hyperthermia has shown to reduce paralysis in EAE, an animal model of human demyelinalin9 diseases. |
| Key Words:
Hyperthermia, Heat shock protein, experimental autoimmune encephalomyelitis，Inflammation |
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