| 섬오갈피 유래 Lupane-triterpene glycoside 화합물의 PC-3
전립선암세포 증식 억제 효과 |
|
부혜진1, 현재희1, 홍지영1, 김상철1, 강정일1, 김영호2, 유은숙1, 강희경1 |
1제주대학교 의학전문대학원 약리학교실
2충남대학교 약학대학 천연물연구실 |
| The antiproliferative effects of lupane-triterpene glycosides from Acanthopanax koreanum in PC-3 human prostate cancer cells |
|
Hye-Jin Boo1, Jae-Hee Hyun1, Ji-Young Hong1, Sang-cheol Kim1, Jung-Il Kang1, Young Ho Kim2, Eun-Sook Yoo1, Hee-Kyoung Kang1 |
1Department of Pharmacology, Jeju National University School of Medicine, Jeju, Korea
2College of Pharmarcy, Chungnam National University, Daejeon, Korea |
Correspondence:
Hee-Kyoung Kang, Email: pharmkhk@jejunu.ac.kr
|
|
|
| Abstract |
|
Acanthopanax koreanum is a medicinal plant native to Korea. Lupane-triterpene glycosides from A. koreanum are known to have various biological activities such as anti-inflammatory, immunostimulatory, and antioxidant effects. However, the anti-cancer activity of lupane-triterpene glycosides in human prostate cancer cells has not been elucidated. We examined the anti-cancer effects of five lupane-Iriterpene glycosides (acankoreoside D, acankoreoside A, acankoreosdie F, acanlrifoside A and acankoreoside K) from A. koreanumin PC-3 prostate cancer cells. When treated with the lupane-triterpene glycosides to PC-3 cells at 50 μ_M, the compounds markedly inhibited (acankoreoside D, 57.7% acankoreoside A. 59.0% acankoreoside F, 49.2% acanlrifoside A, 46.6% and acankoreoside K. 45.4%) the growth of PC-3 cells. The result indicated that the lupane-triterpene glycosides trom A. koreanum could have therapeutic role against prostate cancer. |
| Key Words:
Acanthopanax koreanum; PC-3; Prostate cancer; lupane-triterpene glycosides |
|
PDF Links
Full text via DOI
Download Citation
