| HL-60/MX2 세포에서 제주자생식물 8종의 화학 감작 효능 |
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현재희, 부혜진, 홍지영, 강정일, 김상철, 유은숙, 강희경 |
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제주대학교 의학전문대학원 약리학교실 |
| Chemosensitizing effects of 8 Jeju plants in HL-60/MX2 cell |
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Jae-Hee Hyun, Hye-Jin Boo, Ji-young Hong, Jung-Il Kang, Sang-Cheol Kim, Eun-sook Yoo, Hee-Kyoung Kang |
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Department of Pharmacology, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Hee-Kyoung Kang, Email: pharmkhk@jejunu.ac.kr
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| Abstract |
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One of the major problems in chemotherapy is multidrug resistance (MDR) against anticancer drugs and MDR in cancer cells can lead to chemotherapeutic failure. To overcome MDR, in the study, we investigated the chemosensitizing effectsof 8 Jeju plants in HL-60/MX2 cell, ahuman HL-60 leukemia cell line selected for resistance to mitoxantrone (MX). When HL-60/MX2 cells were treated with 100 ㎍/㎖ of eight plant extracts, Amaranthus mangostanus, Osmanthus heterophylla, Staphylea bumalda and Vicia angustifolia var. segetitis increased MX accumulation in HL-60/MX2 cells by 20.20 %, 19.56 %, 32.84 % and 24.67 %. The present results suggest promising indications for further development of these plant extracts as chemosensitizing agents. |
| Key Words:
HL-60/MX2; chemosensitizing effect; Amaranthus mangostanus; Osmanthus heterophylla; Staphylea bumalda; Vicia angustifolia var. segetilis |
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