| 포유류 면역계 발달과 항상성에 Bacteroides fragilis zwitterionic polysaccharides charge motifs 가 끼치는 영향 |
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이근화 |
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제주대학교 의학전문대학원 미생물학교실 |
| Polysaccharides with zwitterionic charge motifs of Bacteroides fragili can affect both the development and homeostasis of the mammalian immune system |
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Keun-Hwa Lee |
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Departments of Microbiolgy, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Keun-Hwa Lee, Email: yomust7@Jeiunu.ac.kr
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| Abstract |
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Bacterial colonization of the intestine is critical for the normal function of the mammalian immune system. Polysaccharides are characterized as T-cell-independent antigens that are not typically recognized by the full array of immune cells-specifically T cells. However， Bacteroides fragilis zwitterionic polysaccharides charge motifs are processed and presented by the MHC class ll pathway and activate T cells. Namely， Polysaccharide A (PSA) is capable of activating T cell-dependent immune responses that can affect both the development and homeostasis of the host immune system. This molecule also stimulates the innate immune system as a ligand for Toll-like receptor 2 and as such promotes interactions with the adaptive immune system that are required for T cell activation. The study of PSA reveal that polysaccharides of the bacterial microbiota can affect both the development and homeostasis of the mammalian immune system. |
| Key Words:
Bacteroides fragili zwitterionic polysaccharides charge motifs, T cell-dependent immune responses,
Toll-like receptor 2 |
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