| 제주지역 동맥경화정 뇌경색 환자의 Toll-like receptor 4(TLR 4) 유전자의 다형성 |
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이수현1, 최재철2, 이근화1 |
1제주대학교 의학전문대학원 미생물학교실, 환경보건센터(아토피피부염,알레르기비염)
2제주대학교 의학전문대학원 신경과학교실 |
| Toll-like receptor 4 (TLR 4) polymorphisms in atherothrombotic ischemic stroke patients in Jeju |
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Su-Hyun Lee1, Jay-Chol Choi2, Keun Hwa Lee1 |
1Department of Microbiology and The Environmential Health Center(Atopic Dermatitis and Allergic Rhinitis), Jeju National University School of Medicine, Jeju, Korea
2Department of Immunology, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Keun Hwa Lee, Email: yomust7@jejunu.ac.kr
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| Abstract |
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The Toll-like receptor 4(TLR 4) polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is known to be associated with a decreased risk of carotid atherosclerosis. However, whether the TLR 4 polymorphism is also useful in evaluating the risk of alherothrombolic stroke is currently unknown. We investigated the association between the TLR 4 polymorphism and risk of atherothrombotic stroke using a case-control design. This study enrolled 48 stroke patients and the same number of age- and sex-matched controls. All of the subjects in this study underwent a structured interview and had their vascular risk factors assessed. With stroke patients 48 and 48 control group DNA used tlr4 gene amplification and analyzed stroke patients group and control group do not have TLR 4(Asp299Gly) polymorphism. |
| Key Words:
Ischemic stroke; Toll-like receptor 4; Polymorphisms |
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