J Med Life Sci > Volume 8(1); 2011 > Article
Journal of Medicine and Life Science 2011;8(1):35-38.
DOI: https://doi.org/10.22730/jmls.2011.8.1.35    Published online December 30, 2011.
Compound 48/80 으로 자극된 마우스에서 어유의 항소양 효과
한상철1, 강경진1, 강희경1, 문상욱2, 유은숙1
1제주대학교 의과대학 약리학교실
2(주)퍼맨텍
Antipruritic Effect of Fish Oil on Compound 48/80 Stimulated Mice
Sang-Chul Han1, Gyeoung-Jin Kang1, Hee-Kyoung Kang1, Sang-Wook Moon2, Eun-Sook Yoo1
1Department of Pharmacology, School of Medicnine, Jeju National University, Jeju, Korea
2Fermentec Inc. 207, 66. Dae hak Ro, Jeju City, Korea
Correspondence:  Eun-Sook Yoo, Email: eunsyoo@jejunu.ac.kr
Abstract
Itch, a skin sensation that provokes the desire to scratch, accompanies various skin diseases such as atopic dermatitis. In present study, we investigated the anti-pruritic effect of fish oil on scratching behavior mouse models induced by compound 48/80, a mast cell degranulator. Fish oil or diphenhydramine, histamine H1 receptor antagonist, was orally administrated 1 h before subcutaneous injection of compound 48/80. The number of scratching was counted for a period of 20 min after the injection of compound 48/80 and fish oil inhibited the scratching number in a dose-dependent manner, but with potency less than that of diphenhydramine. Also, fish oil suppressed the serum immunoglobulin E (IgE) and histamine induced by compound 48180. Especially, the inhibitory effect of fish oil on histamine release was actually stronger than that of diphenhydramine. Therefore, these results suggest that fish oil may be an effective source for improving allergic symptom of atopic dermatitis.
Key Words: Fish oil; Scratching behavior; Compound 48/80; Histamine; Immunoglobulin E
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