| Transforming Growth Factor-β 가 암발생에 미치는 영향 |
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허규희 |
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제주대학교 의과대학 외과학교실 |
| Transforming Growth Factor-β signaling on tumorigenesis |
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Kyu Hee Her |
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Department of Surgery, College of Medicine, Cheju National University, Jeju 690-756, Korea |
Correspondence:
Kyu Hee Her, Email: herkh@cheju.ac.kr
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| Abstract |
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Transforming growth factor beta (TGF-β ) is a ubiquitous multifunctional polypetide and essential regulator of cellular and physiologic processes including proliferation, differentiation, adhesion, migration, apoptosis, angiogenesis and immunosurveillance. Abnormal activation or inhibition of these TGF-β signaling pathway, including mutation or deletion of members of the signaling pathway and resistance to TGF-β -mediated inhibition of proliferation are frequently observed in human cancers. Although these alterations define a tumor suppressor role for the TGF-β pathway in human cancer, TGF-β also mediates tumor-promoting effects. TGF-β signaling transduction cascade is initiated when TGF-β binds to transmembrane receptors, either through differential effects on tumor and stromal cells or through a fundamental alteration in the TGF-β responsiveness of the tumor cells themselves. In the nucleus, Smads can bind directly to DNA and cooperate with other transcription factors to induce transcription of TGF-β target genes. Ongoing advances in understanding molecular and cellular contexts of this pathway will targeting for the chemoprevention and treatment of human cancers. |
| Key Words:
TGF-β signaling pathway, tumor suppressor, tumor-promoting effects. Smads |
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