J Med Life Sci > Volume 1(1); 2003 > Article
Journal of Medicine and Life Science 2003;1(1):47-51.
DOI: https://doi.org/10.22730/jmls.2003.1.1.47    Published online December 31, 2003.
축삭성 다발신경병증에서 비복/요골 감각신경활동전위 진폭 비의 진단적 유용성
강사윤, 강지훈
제주대학교 의과대학 신경과학교실
The Usefulness of Sural/Radial Amplitude Ratio in the Diagnosis of Mild Axonal Polyneuropathy
Sa-Yoon Kang, Ji-Hoon Kang
Department of Neurology, College of Medicine, Cheju National University, Jeju 690-756, Korea
Correspondence:  Sa-Yoon Kang, Email: neurokang@cheju.ac.kr
Backgrounds and objectives: In the length-dependent axonal polyneuropathy, the distal part of the longer axons are affected earlier. In cases of mild axonal polyneuropathy, nerve conduction studies are frequently normal. We theorized that a sural/radial amplitude ratio (SRAR) might be a sensitive indicator of mild polyneuropathy. We investigated whether the SRAR may be a more sensitive indicator than sural amplitude alone in the diagnosis of mild axonal polyneuropathy. Methods: We analyzed medical records and electrophysiological studies of 32 patients with mild axonal polyneuropathy and 30 normal subjects. Sural amplitudes and SRAR in patients with signs of mild axonal polyneuropathy were compared to those of normal, age-matched control subjects. Sural and radial sensory amplitudes were measured in a standard method in all subjects. Results: Thirty five patients had an average SRAR of 0.26 as compared to 0.65 for the normal subjects. An SRAR of less than 0.50 was a strong predictor of axonal polyneuropathy, with the balance of sensitivity and specificity (80%), as compared to an absolute sural amplitude, which had sensitivity of only 57%. The SRAR did not vary significantly with age. Conclusion: We conclude that the SRAR is a useful electrodiagnostic test for mild axonal polyneuropathy.
Key Words: Axonal polyneuropathy, Sural nerve action potential, Age
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