J Med Life Sci > Volume 9(2); 2012 > Article
Journal of Medicine and Life Science 2012;9(2):78-81.
DOI: https://doi.org/10.22730/jmls.2012.9.2.78    Published online December 18, 2012.
Formoterol has as rapid-acting bronchodilatory effect as salbutamol on the recovery from methacholine-provocating bronchial obstruction
Jong Hoo Lee, Jaechun Lee
Department of lnternal Medicine, Jeju National University School of Medicine, Jeju, South Korea
Correspondence:  Jaechun Lee, Email: doc4u@hanmail.net
Received: 11 October 2012   • Revised: 18 October 2012   • Accepted: 25 October 2012
Abstract
Background
Among inhaled bronchodilators, formoterol is authorized to have rapid-onset bronchodilatory effect as well as its lastingness. In methacholine bronchial provocation test, salbutamol is frequently used for the reverse medication. We compared to the rapidity of bronchodilatory effects between salbutamol in MDl (metered dose inhaler) applied via spacer and formoterol in Turbuhaler.
Methods
A randomized and open-Iabeled study. Subjects were randomized to inhale salbutamol 400ug in MDI via spacer, formoterol 9㎍ in Turbuhaler or placebo in Turbuhafer, when each forced expiratory volume in 1 second falls more than 20% from baseline in bronchial provocation with methacholine. To evaluate rapidity of bronchodilatory effects, recovery times were compared.
Results
The recovery times were 5.28±3.70 min in salbutamol group, 5.78±4.16 min in formoterol group, with no statistical significance (p=0.661). However, in placebo group, significant delay was observed (16.88±5.30 min. p<0.01).
Conclusions
Formoterol in Turbuhaler could be used as rapid-acting bronchodilatory effect as salbutamol in MDI via spacer after bronchial provocation test.
Key Words: Adrenergic beta-2 receptor agonists; Asthma; Bronchial provocation tests; Formoterol; Methacholine chloride
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