J Med Life Sci > Volume 17(2); 2020 > Article
Journal of Medicine and Life Science 2020;17(2):60-63.
DOI: https://doi.org/10.22730/jmls.2020.17.2.60    Published online August 31, 2020.
양측성 부신비대와 알도스테론 생성 선종이 동시에 발현된 증례
박혜원1, 이상아2
1제주대학교 의학전문대학원
2제주대학교 의학전문대학원 내분비대사내과
Primary hyperaldosteronism with aldosterone producing adenoma and hyperplasia: 1 case
Hye Won Park1, Sang Ah Lee2
1Jeju National University School of Medicine, Jeju, Republic of Korea
2Department of Endocrinology and Metabolism Jeju National University School of Medicine, Jeju, Republic of Korea
Correspondence:  Sang Ah Lee, Email: sahe7@hanmail.net
Abstract
Primary hyperaldosteronism is being diagnosed increasingly often. As many as up to 20% of patients with hypertension have the characteristic laboratory increased aldosterone/plasma renin activity ratio. Primary hyperaldosteronism is due to aldosterone-producing adenoma, bilateral adrenal hyperplasia or rarely, adrenal carcinoma or genetic causes. The diagnostic test of hyperaldosteronism is saline loading test usually, captopril test, or other tests. If planned surgery, adrenal vein sampling was necessary for localization. Primary hyperaldosteronism has treated with the aldosterone antagonist spironolactone as the drug of choice. It is used to patients with aldosterone producing adenoma or hyperplasia, because of spironolactone well controlled hypertension in most of primary hyperaldosteronism patients. However, unilateral laparoscopic adrenalectomy is usual treatment for aldosterone producing adenoma or asymmetrical aldostererone production of patients with uncontrolled hypertension. We experienced primary hyperaldosteronism patients successfully treated with unilateral adrenalectomy, who has uncontrolled hypertension through treated with 5 antihypertensive medications and with both adrenal adenoma and adrenal hyperplasia.
Key Words: primary, hyperaldosteronism, adenoma, and, hyperplasia
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