| External Application of Horse Oil Alleviates Atopic
Dermatitis Symptoms in Mice |
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Sang-Hyun Yoon, Na-Jin Kang, Eun-Sook Yoo |
Correspondence:
Eun-Sook Yoo,
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| Abstract |
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Atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. Horse oil,
the purified form from horse fat, has been used for a long time by fork remedies on burn, wound, and various skin diseases. In
this study, we investigated the improving effects of horse oil on atopic dermatitis induced by 0.3% of DNCB in mice. Horse oil B
(oil phase, 100 mg/kg) significantly decreased serum IgE levels in experimental atopic dermatitis mice induced by DNCB. Also,
horse oil A (cream phase, 100 mg/kg) and B alleviates atopic dermatitis symptoms (ear edema, inflammatory cell infiltration, and
lymph node size). Overall, the effect of horse oil B was slightly better. These results suggest that horse oil can be a useful
remedy to improve atopic dermatitis. |
| Key Words:
Horse oil, Atopic dermatitis, 2, 4-Dinitrochlorobenzene, Immunoglobulin E |
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