| Peptide hormone exendin-4 enhances neurogenesis in the dentate gyrus of photochemically induced cerebral ischemia model mice |
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Chang Sub Lee |
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| Abstract |
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Exendin-4 is a peptide resembling GLP-1 (glucagon-like-peptide 1) in the saliva of the glia monster, a poisonous lizard.
Recently, exendin-4 has been reported that stimulates subventricular zone neurogenesis in the adult rodent brain. The author
trying to evaluate the effects of exendin-4 on the neurogenesis in the hippocampus of photochemically induced cerebral
ischemia model mice. Eight week-old male C57/BL6 mice were used. First, rose Bengal was injected via tail vein. After scalp
incision, photothrombic lesion was made on right motor cortex with cool light radiation through optic fiber. Behavior test
(adhesive-tape test) was performed to verify the appropriate brain injury. Daily injection of exendin-4 for 7 days was followed.
Saline was injected in sham operation group. After 3 weeks of holiday, decapitation was performed. Exendin-4 treatment for
one week significantly increases numbers of Ki-67 and BrdU immunoreactive cells in the hippocampus of ischemic model mice.
The present study shows that exendin-4 is able to induce proliferation and differentiation in vivo of neural stem cells form the
adult dentate gyrus and indicates a role for exendin-4 as modulator of neurogenesis of adult brain. |
| Key Words:
cerebral ischemia, exendin-4, neurogenesis |
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